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TW-Real Bifida Ampoule Review – ISNTREE

TW-Real Bifida Ampoule Review – ISNTREE

AD – Sponsored | ISNTREE gifted me their beauty products in exchange for an authentic review.


Many people start using anti-aging products in as early as their 20s because that is when the first signs of aging begin for them. Whether you start out skincare at an early age or have mature skin, look for the Korean beauty brand, ISNTREE TW-Real Bifida Ampoule as this is one of the top contenders in the antiaging skincare products market globally.

In this post “TW-Real Bifida Ampoule Review – ISNTREE”, I will review Isntree TW-Real Bifida Ampoule, 50ml / 1.69 fl. oz., $29.50. If you have maturing or thinning skin, fine lines and wrinkles from pillow creases, butterfly wrinkles, crow’s feet, dull and damaged skin; then this Isntree Bifida review would be helpful for you.


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ISNTREE TW-Real Bifida Ampoule Review

Isntree TW-Real Bifida Ampoule



If you're looking for a vegan, safe, cruelty free, and Green brand, it’s ISNTREE. A clean Korean cosmetics brand that develops highly innovative beauty products one after another for the consumer.

Isntree is one of the best Korean beauty brands. It is a very reasonably priced brand. They are making all their packaging more sustainable this year. Their innovative formulations are customer centered that sell off the shelves; and are a rave in South Korea, and US. And their products are certified.


What Is Isntree TW-Real Bifida Ampoule

Isntree TW-Real Bifida Ampoule, 50ml / 1.69 fl. oz., $29.50, is made to improve skin’s health with its rich nutrients. It is an antiaging skincare product suitable for all skin types and is especially meant to strengthen the skin barrier, maintain skin elasticity, repair damaged skin, reduce fine lines and wrinkles, and even out skin tone. This product is a microbiome technology with the core ingredient 'bifida ferment lysate' at the high concentration of 88% to rejuvenate, and maintain skin elasticity. It has three more vegan fermented extracts from pumpkin, soybean, and rice to protect the skin from environmental stressors and reduces dark spots. It also has three types of peptides for wrinkle care. It is vegan, clean, safe, oil-free, alcohol free, and reef-friendly. ISNTREE Bifida Ampoule has a watery texture, but is very hydrating and moisturizing.


What Is an Ampoule

An ampoule takes sixth place in Korean skin care routine steps. Ampoules and serums are extra strength treatments, sharing the same step. However, the main difference between an ampoule and a serum is that an ampoule is the more potent and concentrated form of serum. Because of that, you apply only a moderate amount on your face.


Isntree Bifida Ampoule Texture and Finish

Isntree Bifida Ampoule is a clear, watery formulation. There is no oil, but the main ingredient bifida ferment lysate is a highly concentrated, oily textured complex, making it the nature derived moisturizing factor. Isntree made the product watery with hydrating ingredients to enhance absorption of the complex ingredient. It is very moisturizing and has a beautiful, luxurious texture that feels like velvet and silk. There is no tackiness. It feels very lightweight on the skin even the next day of wearing it. And it is also easy to layer under makeup.


Skin Type for Isntree Bifida Ampoule

Isntree TW-Real Bifida Ampoule is for all skin types. And it addresses concerns such as fine lines, deep wrinkles, maturing and thinning skin, dull skin, dark spots, damaged skin, and dryness.


Isntree TW-Real Bifida Ampoule – Key Ingredients

The ingredients I love in Isntree Bifida Ampoule are;

  • Bifida ferment lysate 88%, the core ingredient: Maintains skin elasticity, and provides nourishment.
  • Lactobacillus/Pumpkin Ferment Extract, Lactobacillus/Soybean Ferment Extract, Lactobacillus/Rice Ferment Filtrate: Protecting skin barrier from environmental stressors.
  • Palmitoyl Tripeptide-1, Copper tripeptide-1, Acetyl Hexapeptide-8: Wrinkle care.


Isntree Bifida Ampoule Ingredients – Full List

Bifida Ferment Lysate, Dipropylene Glycol, Niacinamide, Glycerin, 1,2-Hexanediol, Butylene Glycol, Illicium Verum (Anise) Fruit Extract, Allantoin, Panthenol, Hydroxyethylcellulose, Water, Scutellaria Baicalensis Root Extract, Arginine, Carbomer, Adenosine, Disodium EDTA, Lactobacillus/Rice Ferment Filtrate, Sodium Hyaluronate, Origanum Vulgare Leaf Extract, Chamaecyparis Obtusa Leaf Extract, Hydrolyzed Collagen, Salix Alba (Willow) Bark Extract, Lactobacillus/​Soybean Ferment Extract, Lactobacillus/​Pumpkin Ferment Extract, Portulaca Oleracea Extract, Cinnamomum Cassia Bark Extract, Beta-Glucan, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Copper Tripeptide-1.


Where to Buy Isntree Bifida Ampoule

Isntree does not sell products from its website anymore. You can look it up for product information and guidance. But to buy it in your region, check out Isntree retailers.


ISNTREE Packaging

Isntree is a green beauty brand. It is responsibly making degradable and eco-friendly packaging in 2022. Some products' packaging is already changed and available in the market. It is now using wash off labels, non-coated packaging, recycled green tea paper, and soy ink. Isntree TW-Real Bifida Ampoule is also available in new packaging. However, there is no change in the formulation.


What Is Bifida Ferment Lysate

In Isntree’s product, Bifida ferment lysate is a fermented microbiome complex that resulted from fermenting and liquefying two bacteria genus i.e. Bifidobacterium, and lactobacillus. This is microbiome technology in which the bacteria goes through several culture processes. Note that the result is NOT a probiotic, but a “complex” that resulted from microbiome methodologies. Microbiome technology is the current popular skincare trend because it gives fast results.


Microbiome vs. Probiotic

This is usually either a misconception, or marketing. Microbiome bioinformatics is a technology that involves methodologies to study nucleic acids’ interactions with each other, and the host in microbial communities. These interactions sometimes result in forming fermented microbiome “complexes”. Whereas, probiotics and prebiotics are health supplements taken orally through the mouth to improve gut health.


What Does Bifida Ferment Lysate Do to Your Skin

Bifida ferment lysate is a healthy bacterial complex for your skin and full of nutrients, proteins and vitamins. It helps to keep your skin healthy and maintain its elasticity, heal damaged skin from environmental stressors and UV rays, and strengthen skin barrier for better immunity.


Should One Use Bifida If the Skin Is Sensitive To Fermented Ingredients

As Isntree bifida ampoule has a very high concentration of bifida ferment lysate 88% along with three other fermented ingredients, the brand recommends you do a patch test if your skin is sensitive to it. But if you still want to try the ingredient but at a lower concentration, then you might want to check out less concentrated alternatives.



Isntree Bifida Ampoule Review

Isntree TW-Real Bifida Ampoule is a microbiome technology. In it the fermented microbiome complex, bifida ferment lysate is a very high end ingredient obtained after few culture steps.

If you wonder does fermented skincare work? Yes, fermented skincare works because the more fermented a formulation is, the more nutrients it has! Fermented skincare ingredients makes your skin healthier, and stronger. This ampoule is high on nutrients to take care of your skin. It might look like common water in appearance but it is your magic potion in a bottle; a queen elixir in antiaging, exactly as Isntree says.

Isntree Bifida ampoule is a niche product for two reasons – microbiome is a new technology that needs awareness; and that this product targets older age groups. That's why it usually gets overlooked over other Isntree products with broader usage.

This ampoule has a beautiful texture. It is watery yet very moisturizing. It feels luxurious on the skin. There is no tackiness. It is very lightweight on the skin and felt the same the next day too. It does not make skin greasy at all. My skin looks hydrated, plump and dewy from it. And it is also layerable under makeup.

As the product has no alcohol in it, it might stay on the skin for some time. It is a fast acting product that gives quick results. It started showing improvements in my skin from the first week of using it.

For best product application, read 'how to use bifida ampoule' below and also, use it in the right season. My skin type is dry and acne prone. I can't go heavy or layer a lot of skin care products. I tried using it once in the very humid and hot weather, but then decided not to. According to my experience, because this product is very moisturizing, it is a great choice for both hot and dry seasons, and winter season with all its weather conditions. Though the brand says that it is for all skin types, I think it might get too moisturizing for oily to very oily skin types, so you might want to test it out first.

I intend to continue buying this product, so I'll update the Isntree TW-Real Bifida Ampoule Review post with its new packaging. This is the third product of the K-beauty brand, Isntree that I'm using and very happy with the results. For me, the name is enough!


Isntree TW-Real Bifida Ampoule How to Use

Isntree directs to apply 2-3 drops on your face and pat for absorption. The product can be used in both AM and PM routines. If you use it in PM, apply it on your face, and then just layer only once at the targeted area(s) where you see any relevant skin issue this product could fix. You can also layer it under makeup.

But how do you use Isntree Bifida ampoule the right way? This is a highly concentrated, but very moisturizing ampoule. If you use too much or with many skincare steps, chances are you might not like it. Less is more. For the right execution and application, follow a minimal skincare steps with this ampoule.

After cleansing my face with face wash, I apply only a few drops (less than half a dropper) of the Isntree bifida ampoule on face and neck, and follow up with a lightweight occlusive moisturizer to lock the product in skin. According to my experience, you do not need to wear a toner, and other essences or serums with this product. Your skin could feel oily with more steps and the product might not perform optimally.


How Is Isntree Bifida Ampoule Different From Competitors

Isntree Bifida Ampoule vs. US Competitors:

The two most talked about US bifida skincare products are Lancome Advanced Genifique Face Serum, 1.7 oz., $115; and Estee Lauder Advanced Night Repair Serum, 1.7 oz., $92.

1. Lancome Advanced Genifique Face Serum vs. Isntree TW-Real Bifida Ampoule:

Isntree bifida ampoule gets a tough competition from the award winning competitor product of Lancome. Subject ingredient is less, but it is known for its formulation and results. A few differences are;

Lancome Advanced Genifique Face Serum has less concentration of bifida 10% as compared to 88% of Isntree bifida.

The breakout controller in Lancome product is vitamin C vs. niacinamide in Isntree bifida.

If you're looking for an alcohol free, clean and vegan product, Isntree bifida ampoule would be your choice.

If your skin is very oily, you may want to opt for Lancome’s product.

Isntree bifida ampoule is economically priced than Lancome Advanced Genifique.

2. Estee Lauder Advanced Night Repair Serum vs. Isntree TW-Real Bifida Ampoule:

Another great but pricey rival is Estee Lauder’s product. Core ingredients are peptides and vitamin E. Bifida is less in amount and serves to nourish skin.

Like Isntree bifida ampoule, Estee Lauder Advanced Night Repair Serum also performs well if used in less quantity.

Estee Lauder product has no fragrance but, Isntree bifida ampoule is the clean, safe, and vegan choice.


Isntree TW-Real Bifida Ampoule vs. Korean Competitors:

There are a few microbiome technology and probiotic related ingredients in Korean skin care. I've picked five bifida ferment lysate serums and ampoules here;

1. Ma:nyo Bifida Biome Complex Ampoule, 1.6 fl. oz., $35: This has many ingredients same as the Isntree bifida ampoule. It also has the antioxidant ginseng extract.

2. Time Revolution Night Repair Ampoule 5X, 1.69 fl. oz., $54: This has 77.2% concentration of ten types of probiotics.

3. Neogen Dermalogy Real Ferment Micro Serum, 1.01 fl. oz., $38: This is an award winning product with great ingredients and formulation. It has 61% of fermented microbiome complex, and vitamins B5, C, and E. I would say that this is a more all-rounder product, and not really a direct competitor of Isntree bifida ampoule because they are very different in formulation. So, you could buy both.

4. Rovectin Clean Forever Young Biome Ampoule, 1.69 fl. oz., $36: A dual biotic and oil-free, clean choice with very good hydration. The texture is a bit thick and might feel slightly tacky on the skin, but absorbs well.

5. Neogen Dermalogy Probiotics Double Action Serum, (22G + 22G), $42: It has two types of serums offering probiotics and hydration. It improves skin barrier function, and hydration level.


All of the above options are great. But ISNTREE TW-Real Bifida Ampoule is different from all of the above over its hardcore formulation, and the highest concentration of microbiome fermented complex ‘bifida ferment lysate 88%’. It is the most economically priced product from all the expensive competitor products making it a great value for money.


Key Decision Making Factors When Choosing To Buy Isntree Bifida Ampoule

Isntree TW-Real Bifida Ampoule is a great value for money as compared to all other expensive competitor products, i.e. 50ml for almost US$30.

You may want to consider how concentrated a fermented ingredient you can use. If you want to go less, then alternatives would be the better choice. If you can tolerate fermented ingredients, try Isntree bifida ampoule.

You may want to see which formulation gives you the desired results according to your skin type. But if you’re more focused on the ingredients, then Isntree bifida ampoule is the clean, safe, and vegan choice.


Pros and Cons

Pros: A highly innovative, hard core formulation. Excellent value for money. Best bifida antiaging product in the global skincare market.

Cons: None at all!


RATING: Isntree TW-Real Bifida Ampoule

Isntree TW-Real Bifida Ampoule Rating - Quantitative Performance (Overall), 5 out of 5 stars. Qualitative Performance, 6 out of 5 stars.


Quantity                       5

Price                            5

Texture                        5

Moisturizing                5

Ingredients                  5

Packaging                   5

Value for money         5



I used the Isntree TW-Real Bifida Ampoule for three months before reviewing it. I first finished the Isntree Chestnut AHA 8% Clear Essence before using this because I wanted my skin nicely exfoliated and prepped to absorb bifida goodness. I must say that this is the first product I have ever given a qualitative rank of 6. It was that good! It suited me very well.

If you are looking for a solid antiaging skincare product, don't hesitate to give it a try. With the right application, it hopefully shouldn’t go wrong. Don't forget to use it in less quantity, and with minimal skincare routine steps.

I am in love with this product and will keep buying more. I have not used such a different texture before. And I can comfortably say that Isntree skincare has easily slided into my top favorite K-beauty brands for my skin type. I have added more of their products in my wish list to try.

That’s all for the Isntree TW-Real Bifida Ampoule Review, another of my Korean beauty reviews! I hope you found it helpful. Let me know in the comment section below what you think. I’ll see you soon again. Bye. Stay safe.


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  1. This is awesome, I will share this with my friend. I think she will find this interesting. Thank you for sharing!

  2. I always wanted to try isntree and this looks like a great option! I have a probiotic serum right now and it’s working well for me, so I think this might really work for me as well! Especially since it also has niacinamide in.

  3. Looks like another great product from Isntree! It's nice they think of sustainability when developing their products.

  4. I haven’t heard of this brand before, but it sounds like it has some great active ingredients. Thank you for sharing your honest thoughts.

    Lauren -

  5. I haven't heard of this brand before, I do like the sound of it though. I like the ingredients that's in the product itself x

    Lucy Mary

  6. I had never heard of Isntree but it sounds divine. I love using clean ingredients in my facial care!

  7. I really enjoy Korean skincare and have heard of this brand for a while now. I recently just saw that a local mall offers these products and I’m so happy to read your review. Once I use up more of my current skincare, I definitely want to give this a try. Thank you for sharing!

  8. Love the sound of this. I must try it.

  9. This was great review and very thorough in every way. You have really done great work and research for this, and it was easy to read - which is difficult to achieve with so chemical topic :)

  10. This sounds like a great little product which really packs a punch. What a great review.


  11. I'm always on the look out for vegan and cruelty-free items like this so thank you for sharing this brand/review. I will have to check it out!

  12. This sounds like a great serum. I haven't heard of the brand before but I like that ifs cruelty free. Thanks for sharing. Jade MumLifeAndMe

  13. The name Isntree is completely new to me. I don't think I ever tried Korean skincare products, but they seem great, so perhaps I should give them a try - Seadbeady Blogs

  14. It was great reading your review for another Isntree product! Ampoules are not something I have tried before as I have always opted for serums instead, but I do like that Isntree is cruelty-free and vegan. The bifida ampoule does sound like a unique product, but since I do have oily skin, I think it might be too moisturizing.

    1. Whenever you buy any products I would like to give some inputs too. Thanks for reading. xx

  15. I love Korean skincare and this ampoule sounds good. I've checked the Korean site of Isntree and they've gave it a new packaging.

    1. Yea i got these when the packaging was under phase. thanks for visiting my page. xx

  16. I love that you compared Isntree to other popular brands in your post. Thank you for the detailed review!

  17. This post is packed full of so much useful information and the products look great. I've never heard of something more potent than a serum. Thanks for sharing.

  18. Great review! Isntree sounds absolutely amazing - and I'm glad it has eco-friendly packaging and caters to all skin types. It sounds like you had some fantastic results! Thank you so much for sharing your thoughts x

  19. I love when an anti-aging product does its job. I'm yet to find one that suits my skin. You spoke highly of this one, may be worth a try. Very informative post

    Jeannie x

    1. I hope it suits you too Jeannie. Thanks for visiting my page! xx

  20. What a fantastic, in-depth review! I love that you list the benefits of this and its ingredients, and go in-depth into the how to use and purpose of this product. I have never tried an ampoule before, but it sounds like it has some serious positives. Thanks for sharing!

  21. I'm glad you liked it Jaya. Thanks for reading!

  22. I haven’t heard of this brand before. You have shared a detailed and in-depth review. Thank you for sharing your experience.

    Lauren - bournemouthgirl


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